Cephalic Disorders

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Holoprosencephaly

The face and forebrain (or prosencephalon) of an embryo normally begin to develop in the 5th and 6th weeks of pregnancy. If the forebrain fails to divide into normal right and left hemispheres, deformities in the face and brain, or holoprosencephaly, results.


Types

The most serious form is alobar holoprosencephaly, in which the hemispheres completely fail to separate. It is characterized by severe facial and brain abnormalities so profound that they often cause int...Read the full article